Lihat sumber Protein tau

'''Protein tau''' () adalah [[protein]] yang membuat [[mikrotubula]] menjadi stabil. Protein tau terdapat sangat banyak pada [[neuron]] di dalam [[sistem saraf pusat]], dan jarang terdapat di lokasi lain.

Protein tau berinteraksi dengan:
* domain SH3 dari [[Fyn kinase]], sebuah [[enzim]] dengan peran penting dalam proses [[mielinasi]] dan diferensiasi morfologis [[oligodendrosit]]<ref>[http://www.ncbi.nlm.nih.gov/pubmed/11826099 Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau]. ''Departments of Neurobiology and Immunology, University of Heidelberg; Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J''.</ref>
* domain terminus-C [[sinuklein]]-alfa, sebuah protein yang terdapat dalam patogenesis beberapa kelainan saraf seperti [[penyakit Parkinson]] dan [[lesi]] seperti [[badan Lewy]]. Sinuklein-alfa kemudian menstimulasi [[protein kinase A]] untuk menginduksi [[fosforilasi]] protein tau.<ref>[http://www.ncbi.nlm.nih.gov/pubmed/10464279 alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356]. ''Department of Medical Biochemistry, University of Aarhus; Jensen PH, Hager H, Nielsen MS, Hojrup P, Gliemann J, Jakes R''.</ref> Proses fosforilasi juga di[[katalis]]asi oleh ''cAMP-dependent'' [[protein kinase]] setelah protein tau terikat pada [[protein 14-3-3zeta]].<ref>[http://www.ncbi.nlm.nih.gov/pubmed/10840038 14-3-3zeta is an effector of tau protein phosphorylation]. ''Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Department of Neurology and Neurosurgery, McGill University; Hashiguchi M, Sobue K, Paudel HK''.</ref>
* domain pengikat [[seng]] dari [[protein S100]].<ref>[http://www.ncbi.nlm.nih.gov/pubmed/11264299 S100beta interaction with tau is promoted by zinc and inhibited by hyperphosphorylation in Alzheimer's disease]. ''Centre for Research in Neurodegenerative Diseases, Department of Pharmacology, University of Toronto; Yu WH, Fraser PE''.</ref><ref>[http://www.ncbi.nlm.nih.gov/pubmed/2833519 Interactions between the microtubule-associated tau proteins and S100b regulate tau phosphorylation by the Ca2+/calmodulin-dependent protein kinase II]. ''Department of Biochemistry, University of California; Baudier J, Cole RD''.</ref>

== Lihat pula ==
* [[Filamen PH]]
* [[Neurita]]

== Referensi ==
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== Sumber dan atribusi ==

Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Protein+tau&oldid=22465673 Wikipedia bahasa Indonesia], revisi 22465673 (2022-12-25T17:23:58Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.

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