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Asam retinoat - Riwayat revisi
2026-09-15T21:36:27Z
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<p>Presentation V4: sitasi, referensi, Math, Wikimedia Commons, dan atribusi</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Revisi sebelumnya</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revisi per 29 Agustus 2026 09.04</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Baris 1:</td>
<td colspan="2" class="diff-lineno">Baris 1:</td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Asam retinoat''' () adalah [[senyawa organik|senyawa]] [[metabolit]] [[retinol|vitamin A]]. Baik [[retinol]], asam retinoat dan beberapa [[retinoid]] sintetik merupakan komponen intrinsik yang penting dalam regulasi [[diferensiasi]] [[sel epitelial]] dan pencegahan [[neoplasma]]. Asam retinoat meningkatkan produksi aktivator [[plasminogen]] jaringan, yang memicu peningkatan aktivitas [[plasmin]] seluler dan mengaktivasi [[hormon TGF|TGF-β]].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Asam retinoat''' () adalah [[senyawa organik|senyawa]] [[metabolit]] [[retinol|vitamin A]]. Baik [[retinol]], asam retinoat dan beberapa [[retinoid]] sintetik merupakan komponen intrinsik yang penting dalam regulasi [[diferensiasi]] [[sel epitelial]] dan pencegahan [[neoplasma]]. Asam retinoat meningkatkan produksi aktivator [[plasminogen]] jaringan, yang memicu peningkatan aktivitas [[plasmin]] seluler dan mengaktivasi [[hormon TGF|TGF-β]].<ins style="font-weight: bold; text-decoration: none;"><ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248210 On the role of transforming growth factor-β in the growth inhibitory effects of retinoic acid in human pancreatic cancer cells]. ''Department of Surgery and Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Department of Biomedical Sciences, Creighton University, Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University; Brahmchetna Singh, Richard F Murphy, Xian-Zhong Ding, Alexandra B Roginsky, Richard H Bell, Jr, dan Thomas E Adrian''.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Pada model [[ayam]], asam retinoat menunjukkan efektivitas lebih tinggi daripada retinol saat mengubah [[metaplasia]] yang menjadi telah [[keratin]], menjadi metaplasia [[mukus]]. ''Methylketocyclopentenyl'' dan 1-''methoxyethylcyclopentenyl'', senyawa analog dari asam retinoat-β, paling tidak 50 kali lebih efektif daripada asam retinoat, untuk menghambat [[hiperplasia]] yang diinduksi oleh [[karsinogen]].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Pada model [[ayam]], asam retinoat menunjukkan efektivitas lebih tinggi daripada retinol saat mengubah [[metaplasia]] yang menjadi telah [[keratin]], menjadi metaplasia [[mukus]].<ins style="font-weight: bold; text-decoration: none;"><ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1184018/pdf/biochemj00487-0195.pdf Determination of Binding Affinities of Retinoids to Retinoic Acid-Binding Protein and Serum Albumin]. ''Southern Research Institute; BRAHMA P. SANI, BELINDA C. TITUS dan CHANDRA K. BANERJEE''.</ref> </ins>''Methylketocyclopentenyl'' dan 1-''methoxyethylcyclopentenyl'', senyawa analog dari asam retinoat-β, paling tidak 50 kali lebih efektif daripada asam retinoat, untuk menghambat [[hiperplasia]] yang diinduksi oleh [[karsinogen]].<ins style="font-weight: bold; text-decoration: none;"><ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801872/pdf/canmedaj01131-0025.pdf Inhibition of carcinogenesis by retinoids]. ''PAUL NETTESHEIM''.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Senyawa [[retinoid]] asam retinoat lain, seperti ''all-trans retinoic acid'', ''13-cis retinoic acid'', dan ''arotinoid Ro 13-6298'', sangat efektif menghambat aktivitas [[transglutaminase]] pada [[sel kanker|sel]] [[karsinoma skuamus]] SCC-13, tanpa adanya [[hormon]] ''hydrocortisone''.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Senyawa [[retinoid]] asam retinoat lain, seperti ''all-trans retinoic acid'', ''13-cis retinoic acid'', dan ''arotinoid Ro 13-6298'', sangat efektif menghambat aktivitas [[transglutaminase]] pada [[sel kanker|sel]] [[karsinoma skuamus]] SCC-13, tanpa adanya [[hormon]] ''hydrocortisone''.<ins style="font-weight: bold; text-decoration: none;"><ref>[http://www.ncbi.nlm.nih.gov/pubmed/2862088 Retinoid suppression of transglutaminase activity and envelope competence in cultured human epidermal carcinoma cells. Hydrocortisone is a potent antagonist or retinyl acetate but not retinoic acid]. ''Thacher SM, Coe EL, Rice RH''.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Pranala luar ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Pranala luar ==</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l10">Baris 10:</td>
<td colspan="2" class="diff-lineno">Baris 10:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801872/pdf/canmedaj01131-0025.pdf Inhibition of carcinogenesis by retinoids]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801872/pdf/canmedaj01131-0025.pdf Inhibition of carcinogenesis by retinoids]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== <del style="font-weight: bold; text-decoration: none;">Rujukan </del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== <ins style="font-weight: bold; text-decoration: none;">Referensi </ins>==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><references /></ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Sumber dan atribusi ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Sumber dan atribusi ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Asam+retinoat&oldid=29150071 Wikipedia bahasa Indonesia], revisi 29150071 (2026-04-21T16:32:27Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Asam+retinoat&oldid=29150071 Wikipedia bahasa Indonesia], revisi 29150071 (2026-04-21T16:32:27Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</div></td></tr>
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<p>Impor teks terkontrol dari Wikipedia bahasa Indonesia; revisi 29150071; atribusi sumber disertakan.</p>
<p><b>Halaman baru</b></p><div>'''Asam retinoat''' () adalah [[senyawa organik|senyawa]] [[metabolit]] [[retinol|vitamin A]]. Baik [[retinol]], asam retinoat dan beberapa [[retinoid]] sintetik merupakan komponen intrinsik yang penting dalam regulasi [[diferensiasi]] [[sel epitelial]] dan pencegahan [[neoplasma]]. Asam retinoat meningkatkan produksi aktivator [[plasminogen]] jaringan, yang memicu peningkatan aktivitas [[plasmin]] seluler dan mengaktivasi [[hormon TGF|TGF-β]].<br />
<br />
Pada model [[ayam]], asam retinoat menunjukkan efektivitas lebih tinggi daripada retinol saat mengubah [[metaplasia]] yang menjadi telah [[keratin]], menjadi metaplasia [[mukus]]. ''Methylketocyclopentenyl'' dan 1-''methoxyethylcyclopentenyl'', senyawa analog dari asam retinoat-β, paling tidak 50 kali lebih efektif daripada asam retinoat, untuk menghambat [[hiperplasia]] yang diinduksi oleh [[karsinogen]].<br />
<br />
Senyawa [[retinoid]] asam retinoat lain, seperti ''all-trans retinoic acid'', ''13-cis retinoic acid'', dan ''arotinoid Ro 13-6298'', sangat efektif menghambat aktivitas [[transglutaminase]] pada [[sel kanker|sel]] [[karsinoma skuamus]] SCC-13, tanpa adanya [[hormon]] ''hydrocortisone''.<br />
<br />
== Pranala luar ==<br />
* [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC370976/pdf/jcinvest00478-0029.pdf Retinoic Acid, INHIBITION OF THE CLONAL GROWTH OF HUMAN MYELOID LEUKEMIA CELLS]<br />
* [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC345571/pdf/pnas00615-0047.pdf Differences in keratin synthesis between normal epithelial cells and squamous cell carcinomas are mediated by vitamin A]<br />
* [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1801872/pdf/canmedaj01131-0025.pdf Inhibition of carcinogenesis by retinoids]<br />
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== Rujukan ==<br />
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== Sumber dan atribusi ==<br />
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Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Asam+retinoat&oldid=29150071 Wikipedia bahasa Indonesia], revisi 29150071 (2026-04-21T16:32:27Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</div>
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