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CD44 - Riwayat revisi
2026-09-15T12:38:47Z
Riwayat revisi halaman ini di wiki
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https://wiki.unissula.ac.id/index.php?title=CD44&diff=27373&oldid=prev
Maintenance script: Presentation V4: sitasi, referensi, Math, Wikimedia Commons, dan atribusi
2026-08-29T18:01:53Z
<p>Presentation V4: sitasi, referensi, Math, Wikimedia Commons, dan atribusi</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Revisi sebelumnya</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revisi per 29 Agustus 2026 18.01</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Baris 1:</td>
<td colspan="2" class="diff-lineno">Baris 1:</td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">'''CD44''' adalah </del>[[<del style="font-weight: bold; text-decoration: none;">kluster diferensiasi</del>|<del style="font-weight: bold; text-decoration: none;">ekspresi]] [[ekspresi gen</del>|<del style="font-weight: bold; text-decoration: none;">gen]] berupa [[glikoprotein]] [[membran sel#membran sel eukariota#protein transmembran</del>|<del style="font-weight: bold; text-decoration: none;">transmembran]] yang banyak mengalami variasi proteolitik. Isoform berupa CD44v banyak terdapat pada sel sekretori di sekitar [[kelenjar]] [[prostat]], sedangkan ekspresi CD44s ditemukan pada seluruh jenis [[sel epitelial]]. Terganggunya ekspresi </del>CD44 <del style="font-weight: bold; text-decoration: none;">akan memungkinkan pertumbuhan [[tumor</del>]] <del style="font-weight: bold; text-decoration: none;">dan invasinya menjadi [[kanker]].</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[<ins style="font-weight: bold; text-decoration: none;">File:Protein_CD44_PDB_1poz.png</ins>|<ins style="font-weight: bold; text-decoration: none;">thumb|right</ins>|<ins style="font-weight: bold; text-decoration: none;">280px</ins>|<ins style="font-weight: bold; text-decoration: none;">Protein </ins>CD44 <ins style="font-weight: bold; text-decoration: none;">PDB 1poz</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Pada </del>[[<del style="font-weight: bold; text-decoration: none;">kanker prostat</del>]]<del style="font-weight: bold; text-decoration: none;">, </del>[[<del style="font-weight: bold; text-decoration: none;">hormon</del>]] [[<del style="font-weight: bold; text-decoration: none;">kalsitonin</del>]] <del style="font-weight: bold; text-decoration: none;">berperan sebagai </del>[[<del style="font-weight: bold; text-decoration: none;">faktor pertumbuhan]] [[parakrin</del>]] yang <del style="font-weight: bold; text-decoration: none;">menginduksi ekspresi varian CD44 yaitu CD44v7-10 melalui lintasan </del>[<del style="font-weight: bold; text-decoration: none;">[protein </del>kinase A<del style="font-weight: bold; text-decoration: none;">]] </del>dan [[<del style="font-weight: bold; text-decoration: none;">p38</del>]]<del style="font-weight: bold; text-decoration: none;">. CD44v7-10 memiliki daya cerap lebih besar terhadap </del>[[<del style="font-weight: bold; text-decoration: none;">fibronektin</del>]] <del style="font-weight: bold; text-decoration: none;">daripada senyawa </del>[[<del style="font-weight: bold; text-decoration: none;">hialuronan</del>]] <del style="font-weight: bold; text-decoration: none;">yang biasa dicerapnya, dan mengaktivasi </del>[[<del style="font-weight: bold; text-decoration: none;">lintasan metabolisme|lintasan</del>]] [[<del style="font-weight: bold; text-decoration: none;">Kinase MAP|MAPK</del>]].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''CD44''' adalah </ins>[[<ins style="font-weight: bold; text-decoration: none;">kluster diferensiasi|ekspresi</ins>]] [[<ins style="font-weight: bold; text-decoration: none;">ekspresi gen|gen</ins>]] <ins style="font-weight: bold; text-decoration: none;">berupa </ins>[[<ins style="font-weight: bold; text-decoration: none;">glikoprotein</ins>]] [[<ins style="font-weight: bold; text-decoration: none;">membran sel#membran sel eukariota#protein transmembran|transmembran</ins>]] yang <ins style="font-weight: bold; text-decoration: none;">banyak mengalami variasi proteolitik.<ref></ins>[<ins style="font-weight: bold; text-decoration: none;">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551621 MAP </ins>kinase <ins style="font-weight: bold; text-decoration: none;">pathways and calcitonin influence CD44 alternate isoform expression in prostate cancer cells]. ''Department of Pathology, Anschutz Medical Campus, University of Colorado Denver; Eric W Robbins, Emily </ins>A <ins style="font-weight: bold; text-decoration: none;">Travanty, Kui Yang, </ins>dan <ins style="font-weight: bold; text-decoration: none;">Kenneth A Iczkowski''.</ref> Isoform berupa CD44v banyak terdapat pada sel sekretori di sekitar </ins>[[<ins style="font-weight: bold; text-decoration: none;">kelenjar</ins>]] [[<ins style="font-weight: bold; text-decoration: none;">prostat</ins>]]<ins style="font-weight: bold; text-decoration: none;">, sedangkan ekspresi CD44s ditemukan pada seluruh jenis </ins>[[<ins style="font-weight: bold; text-decoration: none;">sel epitelial</ins>]]<ins style="font-weight: bold; text-decoration: none;">. Terganggunya ekspresi CD44 akan memungkinkan pertumbuhan </ins>[[<ins style="font-weight: bold; text-decoration: none;">tumor</ins>]] <ins style="font-weight: bold; text-decoration: none;">dan invasinya menjadi </ins>[[<ins style="font-weight: bold; text-decoration: none;">kanker</ins>]].</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== Rujukan ==</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Pada [[kanker prostat]], [[hormon]] [[kalsitonin]] berperan sebagai [[faktor pertumbuhan]] [[parakrin]] yang menginduksi ekspresi varian CD44 yaitu CD44v7-10 melalui lintasan [[protein kinase A]] dan [[p38]]. CD44v7-10 memiliki daya cerap lebih besar terhadap [[fibronektin]] daripada senyawa [[hialuronan]] yang biasa dicerapnya,<ref>[http://www.ncbi.nlm.nih.gov/pubmed/16886606 The predominant CD44 splice variant in prostate cancer binds fibronectin, and calcitonin stimulates its expression]. ''Department of Pathology, The University of Florida, Veterans Administration Medical Center; Iczkowski KA, Omara-Opyene AL, Shah GV''.</ref> dan mengaktivasi [[lintasan metabolisme|lintasan]] [[Kinase MAP|MAPK]].</ins></div></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Referensi ==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><references /></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Sumber dan atribusi ==</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== <del style="font-weight: bold; text-decoration: none;">Sumber </del>dan <del style="font-weight: bold; text-decoration: none;">atribusi ==</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title</ins>=<ins style="font-weight: bold; text-decoration: none;">CD44&oldid</ins>=<ins style="font-weight: bold; text-decoration: none;">26994284 Wikipedia bahasa Indonesia], revisi 26994284 (2025-03-04T17:36:26Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Gambar pada artikel ini bersumber dari Wikimedia Commons </ins>dan <ins style="font-weight: bold; text-decoration: none;">mengikuti ketentuan lisensi masing-masing berkas. Mohon gunakan konten dan media secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=CD44&oldid=26994284 Wikipedia bahasa Indonesia], revisi 26994284 (2025</del>-<del style="font-weight: bold; text-decoration: none;">03</del>-<del style="font-weight: bold; text-decoration: none;">04T17:36:26Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi</del>-<del style="font-weight: bold; text-decoration: none;">BerbagiSerupa (CC BY</del>-<del style="font-weight: bold; text-decoration: none;">SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><!</ins>-- <ins style="font-weight: bold; text-decoration: none;">WIKI_UNISSULA_PRESENTATION_V4 </ins>--<ins style="font-weight: bold; text-decoration: none;">></ins></div></td></tr>
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https://wiki.unissula.ac.id/index.php?title=CD44&diff=26973&oldid=prev
Maintenance script: Impor teks terkontrol dari Wikipedia bahasa Indonesia; revisi 26994284; atribusi sumber disertakan.
2026-08-29T17:23:50Z
<p>Impor teks terkontrol dari Wikipedia bahasa Indonesia; revisi 26994284; atribusi sumber disertakan.</p>
<p><b>Halaman baru</b></p><div>'''CD44''' adalah [[kluster diferensiasi|ekspresi]] [[ekspresi gen|gen]] berupa [[glikoprotein]] [[membran sel#membran sel eukariota#protein transmembran|transmembran]] yang banyak mengalami variasi proteolitik. Isoform berupa CD44v banyak terdapat pada sel sekretori di sekitar [[kelenjar]] [[prostat]], sedangkan ekspresi CD44s ditemukan pada seluruh jenis [[sel epitelial]]. Terganggunya ekspresi CD44 akan memungkinkan pertumbuhan [[tumor]] dan invasinya menjadi [[kanker]].<br />
<br />
Pada [[kanker prostat]], [[hormon]] [[kalsitonin]] berperan sebagai [[faktor pertumbuhan]] [[parakrin]] yang menginduksi ekspresi varian CD44 yaitu CD44v7-10 melalui lintasan [[protein kinase A]] dan [[p38]]. CD44v7-10 memiliki daya cerap lebih besar terhadap [[fibronektin]] daripada senyawa [[hialuronan]] yang biasa dicerapnya, dan mengaktivasi [[lintasan metabolisme|lintasan]] [[Kinase MAP|MAPK]].<br />
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== Rujukan ==<br />
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== Sumber dan atribusi ==<br />
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Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=CD44&oldid=26994284 Wikipedia bahasa Indonesia], revisi 26994284 (2025-03-04T17:36:26Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</div>
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