https://wiki.unissula.ac.id/index.php?action=history&feed=atom&title=Endotelial_lipase Endotelial lipase - Riwayat revisi 2026-09-16T09:16:15Z Riwayat revisi halaman ini di wiki MediaWiki 1.46.0 https://wiki.unissula.ac.id/index.php?title=Endotelial_lipase&diff=26569&oldid=prev Maintenance script: Presentation V4: sitasi, referensi, Math, Wikimedia Commons, dan atribusi 2026-08-29T14:00:30Z <p>Presentation V4: sitasi, referensi, Math, Wikimedia Commons, dan atribusi</p> <table style="background-color: #fff; color: #202122;" data-mw-interface=""> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="id"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Revisi sebelumnya</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revisi per 29 Agustus 2026 14.00</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Baris 1:</td> <td colspan="2" class="diff-lineno">Baris 1:</td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Lipase endotelial''' () merupakan [[enzim]] dari jenis [[lipase]] hasil [[sekresi]] [[sel endotelial]] lebih memiliki aktivitas [[katalis|katalitik]] sebagai [[fosfolipase A1]], selain [[trigliserida]]-lipase dan [[fosfatidil kolina]]-lipase. Sekresi berlebih dari EL akan menurunkan [[plasma darah|plasma]] [[lipoprotein densitas tinggi|HDL]]-[[kolesterol|C]] dan [[senyawa organik|senyawa]] [[protein]] utama yang dikandungnya yaitu [[apolipoprotein A-I]]. EL juga mencerap [[heparin]], dan meningkatkan kandungan [[kolesterol]] di dalam [[hati]].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Lipase endotelial''' () merupakan [[enzim]] dari jenis [[lipase]] hasil [[sekresi]] [[sel endotelial]] lebih memiliki aktivitas [[katalis|katalitik]] sebagai [[fosfolipase A1]],<ins style="font-weight: bold; text-decoration: none;">&lt;ref&gt;[http://www.ncbi.nlm.nih.gov/pubmed/15023297 Endothelial lipase and cholesterol metabolism]. ''Section of Cardiology and Atherosclerosis, Baylor College of Medicine; Cilingiroglu M, Ballantyne C''.&lt;/ref&gt; </ins>selain [[trigliserida]]-lipase dan [[fosfatidil kolina]]-lipase.<ins style="font-weight: bold; text-decoration: none;">&lt;ref&gt;[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749106 Identification of the Active Form of Endothelial Lipase, a Homodimer in a Head-to-Tail Conformation]. ''Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, and Institute for Diabetes Obesity and Metabolism, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, NIAMS, National Institutes of Health, Department of Chemistry, University of Pennsylvania, University of Pennsylvania School of Nursing, Nathalie Griffon, Weijin Jin, Thomas J. Petty, John Millar, Karen O. Badellino, Jeffery G. Saven, Dawn H. Marchadier, Ellis S. Kempner, Jeffrey Billheimer, Jane M. Glick, dan Daniel J. Rader''.&lt;/ref&gt; </ins>Sekresi berlebih dari EL akan menurunkan [[plasma darah|plasma]] [[lipoprotein densitas tinggi|HDL]]-[[kolesterol|C]] dan [[senyawa organik|senyawa]] [[protein]] utama yang dikandungnya yaitu [[apolipoprotein A-I]].<ins style="font-weight: bold; text-decoration: none;">&lt;ref&gt;[http://www.ncbi.nlm.nih.gov/pubmed/10192396 A novel endothelial-derived lipase that modulates HDL metabolism]. ''Cardiovascular Biology Department, Rhone-Poulenc Rorer Research and Development; Jaye M, Lynch KJ, Krawiec J, Marchadier D, Maugeais C, Doan K, South V, Amin D, Perrone M, Rader DJ''.&lt;/ref&gt; </ins>EL juga mencerap [[heparin]],<ins style="font-weight: bold; text-decoration: none;">&lt;ref&gt;[http://www.uniprot.org/uniprot/Q9Y5X9 Q9Y5X9 (LIPE_HUMAN) Reviewed]. ''UniProt''.&lt;/ref&gt; </ins>dan meningkatkan kandungan [[kolesterol]] di dalam [[hati]].<ins style="font-weight: bold; text-decoration: none;">&lt;ref&gt;[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724056 Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice]. ''Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Medical Center Groningen, University of Groningen, Harmen Wiersma, Alberto Gatti, Niels Nijstad, Folkert Kuipers, dan Uwe J. F. Tietge''.&lt;/ref&gt;</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Aktivitas EL terhadap HDL akan menghasilkan senyawa [[palmitoil lisofosfatidilkolina|LPC 16:0]], [[linoleoil lisofosfatidilkolina|LPC 18:2]], [[arakidonoil lisofosfatidilkolina|LPC 20:4]] dan [[oleoil lisofosfatidilkolina|LPC 18:1]]. Sering kali LPC 18:C bersifat pasif, namun jenis LPC yang lain aktif menstimulasi [[sekresi]] [[sitokina]] [[interleukin-8|IL-8]] [[aterosklerosis|aterogenik]] dan [[prostasilin|PGI-2]] dari sel endotelial dan meningkatkan penyerapan [[kalsium|Ca&lt;sup&gt;2+&lt;/sup&gt;]] ke dalam [[sitoplasma]] [[sel (biologi)|sel]] tersebut.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Aktivitas EL terhadap HDL akan menghasilkan senyawa [[palmitoil lisofosfatidilkolina|LPC 16:0]], [[linoleoil lisofosfatidilkolina|LPC 18:2]], [[arakidonoil lisofosfatidilkolina|LPC 20:4]] dan [[oleoil lisofosfatidilkolina|LPC 18:1]].<ins style="font-weight: bold; text-decoration: none;">&lt;ref&gt;[http://www.ncbi.nlm.nih.gov/pubmed/21130993 Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells]. ''Institute of Molecular Biology and Biochemistry, Riederer M, Lechleitner M, Hrzenjak A, Koefeler H, Desoye G, Heinemann A, Frank S''.&lt;/ref&gt; </ins>Sering kali LPC 18:C bersifat pasif, namun jenis LPC yang lain aktif menstimulasi [[sekresi]] [[sitokina]] [[interleukin-8|IL-8]] [[aterosklerosis|aterogenik]] dan [[prostasilin|PGI-2]] dari sel endotelial dan meningkatkan penyerapan [[kalsium|Ca&lt;sup&gt;2+&lt;/sup&gt;]] ke dalam [[sitoplasma]] [[sel (biologi)|sel]] tersebut.<ins style="font-weight: bold; text-decoration: none;">&lt;ref&gt;</ins>[<ins style="font-weight: bold; text-decoration: none;">http://www.ncbi.nlm.nih.gov/pubmed/20610733 Acyl chain</ins>-<ins style="font-weight: bold; text-decoration: none;">dependent effect of lysophosphatidylcholine on endothelial prostacyclin production</ins>]<ins style="font-weight: bold; text-decoration: none;">. ''Institute of Molecular Biology and Biochemistry, University of Helsinki; Riederer M, Ojala PJ, Hrzenjak A, Graier WF, Malli R, Tritscher M, Hermansson M, Watzer B, Schweer H, Desoye G, Heinemann A</ins>, <ins style="font-weight: bold; text-decoration: none;">Frank S''</ins>.<ins style="font-weight: bold; text-decoration: none;">&lt;/ref&gt;</ins></div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[<del style="font-weight: bold; text-decoration: none;">[Protein ANGPTL-3|ANGPTL</del>-<del style="font-weight: bold; text-decoration: none;">3</del>]<del style="font-weight: bold; text-decoration: none;">] merupakan [[senyawa organik|senyawa]] penghambat EL</del>, <del style="font-weight: bold; text-decoration: none;">berupa irisan protein dari lintasan proteolitik enzim [[proprotein konvertase]] yang disekresi oleh [[hati]]</del>.</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== Rujukan ==</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Protein ANGPTL-3|ANGPTL-3]] merupakan [[senyawa organik|senyawa]] penghambat EL, berupa irisan protein dari lintasan proteolitik enzim [[proprotein konvertase]] yang disekresi oleh [[hati]].&lt;ref&gt;[http://www.ncbi.nlm.nih.gov/pubmed/17681148 Hepatic proprotein convertases modulate HDL metabolism]. ''Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine; Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, Rader DJ''.&lt;/ref&gt;</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Referensi ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;references /&gt;</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Sumber dan atribusi ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Sumber dan atribusi ==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Endotelial+lipase&amp;oldid=29600442 Wikipedia bahasa Indonesia], revisi 29600442 (2026-08-19T13:28:21Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Endotelial+lipase&amp;oldid=29600442 Wikipedia bahasa Indonesia], revisi 29600442 (2026-08-19T13:28:21Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;!-- WIKI_UNISSULA_PRESENTATION_V4 --&gt;</ins></div></td></tr> </table> Maintenance script https://wiki.unissula.ac.id/index.php?title=Endotelial_lipase&diff=26171&oldid=prev Maintenance script: Impor teks terkontrol dari Wikipedia bahasa Indonesia; revisi 29600442; atribusi sumber disertakan. 2026-08-29T13:22:17Z <p>Impor teks terkontrol dari Wikipedia bahasa Indonesia; revisi 29600442; atribusi sumber disertakan.</p> <p><b>Halaman baru</b></p><div>&#039;&#039;&#039;Lipase endotelial&#039;&#039;&#039; () merupakan [[enzim]] dari jenis [[lipase]] hasil [[sekresi]] [[sel endotelial]] lebih memiliki aktivitas [[katalis|katalitik]] sebagai [[fosfolipase A1]], selain [[trigliserida]]-lipase dan [[fosfatidil kolina]]-lipase. Sekresi berlebih dari EL akan menurunkan [[plasma darah|plasma]] [[lipoprotein densitas tinggi|HDL]]-[[kolesterol|C]] dan [[senyawa organik|senyawa]] [[protein]] utama yang dikandungnya yaitu [[apolipoprotein A-I]]. EL juga mencerap [[heparin]], dan meningkatkan kandungan [[kolesterol]] di dalam [[hati]].<br /> <br /> Aktivitas EL terhadap HDL akan menghasilkan senyawa [[palmitoil lisofosfatidilkolina|LPC 16:0]], [[linoleoil lisofosfatidilkolina|LPC 18:2]], [[arakidonoil lisofosfatidilkolina|LPC 20:4]] dan [[oleoil lisofosfatidilkolina|LPC 18:1]]. Sering kali LPC 18:C bersifat pasif, namun jenis LPC yang lain aktif menstimulasi [[sekresi]] [[sitokina]] [[interleukin-8|IL-8]] [[aterosklerosis|aterogenik]] dan [[prostasilin|PGI-2]] dari sel endotelial dan meningkatkan penyerapan [[kalsium|Ca&lt;sup&gt;2+&lt;/sup&gt;]] ke dalam [[sitoplasma]] [[sel (biologi)|sel]] tersebut.<br /> <br /> [[Protein ANGPTL-3|ANGPTL-3]] merupakan [[senyawa organik|senyawa]] penghambat EL, berupa irisan protein dari lintasan proteolitik enzim [[proprotein konvertase]] yang disekresi oleh [[hati]].<br /> <br /> == Rujukan ==<br /> <br /> <br /> <br /> == Sumber dan atribusi ==<br /> <br /> Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Endotelial+lipase&amp;oldid=29600442 Wikipedia bahasa Indonesia], revisi 29600442 (2026-08-19T13:28:21Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</div> Maintenance script