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Leukotriena - Riwayat revisi
2026-09-16T04:13:04Z
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<p>Presentation V4: sitasi, referensi, Math, Wikimedia Commons, dan atribusi</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Revisi sebelumnya</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revisi per 29 Agustus 2026 14.06</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Baris 1:</td>
<td colspan="2" class="diff-lineno">Baris 1:</td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">'''Leukotriena''' adalah famili </del>[[<del style="font-weight: bold; text-decoration: none;">Radang</del>|<del style="font-weight: bold; text-decoration: none;">mediator inflamasi]] [[eikosanoid]] yang diproduksi dalam [[sel darah putih]] oleh [[Redoks</del>|<del style="font-weight: bold; text-decoration: none;">oksidasi]] [[asam arakidonat]] (AA) </del>dan <del style="font-weight: bold; text-decoration: none;">[[asam lemak esensial]] yaitu [[asam eikosapentanoat]] (EPA) oleh [[enzim</del>]] <del style="font-weight: bold; text-decoration: none;">[[5-lipokigenase arakidonat]].</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[<ins style="font-weight: bold; text-decoration: none;">File:Leukotriene_A4.svg</ins>|<ins style="font-weight: bold; text-decoration: none;">thumb|right|280px</ins>|<ins style="font-weight: bold; text-decoration: none;">Leukotriena A 4 . Perhatikan empat ikatan rangkap, tiga di antaranya terkonjugasi. Struktur ini umum pada A4, B4, C4, D4, </ins>dan <ins style="font-weight: bold; text-decoration: none;">E4</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Leukotriena <del style="font-weight: bold; text-decoration: none;">menggunakan </del>[[<del style="font-weight: bold; text-decoration: none;">persinyalan lipid</del>]] <del style="font-weight: bold; text-decoration: none;">untuk menyampaikan informasi baik ke </del>sel <del style="font-weight: bold; text-decoration: none;">yang memproduksinya </del>([[<del style="font-weight: bold; text-decoration: none;">persinyalan autokrin</del>]]<del style="font-weight: bold; text-decoration: none;">) atau sel-sel tetangga (</del>[[<del style="font-weight: bold; text-decoration: none;">persinyalan parakrin</del>]]) <del style="font-weight: bold; text-decoration: none;">untuk mengatur respons imun. Produksi leukotriena biasanya disertai dengan produksi </del>[[<del style="font-weight: bold; text-decoration: none;">histamin</del>]] <del style="font-weight: bold; text-decoration: none;">dan </del>[[<del style="font-weight: bold; text-decoration: none;">prostaglandin</del>]], <del style="font-weight: bold; text-decoration: none;">yang juga bertindak sebagai mediator inflamasi</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>Leukotriena<ins style="font-weight: bold; text-decoration: none;">''' adalah famili </ins>[[<ins style="font-weight: bold; text-decoration: none;">Radang|mediator inflamasi]] [[eikosanoid</ins>]] <ins style="font-weight: bold; text-decoration: none;">yang diproduksi dalam [[</ins>sel <ins style="font-weight: bold; text-decoration: none;">darah putih]] oleh [[Redoks|oksidasi]] [[asam arakidonat]] </ins>(<ins style="font-weight: bold; text-decoration: none;">AA) dan </ins>[[<ins style="font-weight: bold; text-decoration: none;">asam lemak esensial</ins>]] <ins style="font-weight: bold; text-decoration: none;">yaitu </ins>[[<ins style="font-weight: bold; text-decoration: none;">asam eikosapentanoat</ins>]] <ins style="font-weight: bold; text-decoration: none;">(EPA</ins>) <ins style="font-weight: bold; text-decoration: none;">oleh </ins>[[<ins style="font-weight: bold; text-decoration: none;">enzim</ins>]] [[<ins style="font-weight: bold; text-decoration: none;">5-lipokigenase arakidonat</ins>]]<ins style="font-weight: bold; text-decoration: none;">.<ref>H. Loick. ''Die Eicosanoide als Mediatoren beim ARDS''. ''Anästhesiologie, Intensivmedizin, Notfallmedizin</ins>, <ins style="font-weight: bold; text-decoration: none;">Schmerztherapie''. 1994. Vol. 29 (1). hlm. 3–9. doi:10.1055/s-2007-996677.</ref><ref>John A Salmon. [http://bmb.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=2825898 Prostaglandins and leukotrienes as inflammatory mediators]. ''British Medical Bulletin''. 1987. Vol. 43 (2). hlm. 285–96. doi:10.1093/oxfordjournals.bmb.a072183.</ref><ref>Paul M. O'Byrne. [https://archive.org/details/sim_annals-of-internal-medicine_1997-09-15_127_6/page/472 Antileukotrienes in the treatment of asthma]. ''Annals of Internal Medicine''. 1997. Vol. 127 (6). hlm. 472–80. doi:10.7326/0003-4819-127-6-199709150-00009</ins>.<ins style="font-weight: bold; text-decoration: none;"></ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Salah satu peran mereka (khususnya, [[Leukotriena D4|leukotriena D<sub>4</sub>]]) adalah memicu kontraksi pada otot polos yang melapisi bronkiolus; produksi berlebih leukotriena merupakan penyebab utama peradangan pada [[asma]] dan [[rhinitis]] alergik. [[Antagonis leukotriena]] digunakan untuk mengobati gangguan ini dengan menghambat produksi atau aktivitas leukotriena.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Leukotriena menggunakan [[persinyalan lipid]] untuk menyampaikan informasi baik ke sel yang memproduksinya ([[persinyalan autokrin]]) atau sel-sel tetangga ([[persinyalan parakrin]]) untuk mengatur respons imun. Produksi leukotriena biasanya disertai dengan produksi [[histamin]] dan [[prostaglandin]], yang juga bertindak sebagai mediator inflamasi.<ref>Martha White. [https://www.jacionline.org/article/S0091-6749(99)70215-0/pdf Mediators of inflammation and the inflammatory process]. ''The Journal of Allergy and Clinical Immunology''. 1999. Vol. 103.</ref></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Salah satu peran mereka (khususnya, [[Leukotriena D4|leukotriena D<sub>4</sub>]]) adalah memicu kontraksi pada otot polos yang melapisi bronkiolus; produksi berlebih leukotriena merupakan penyebab utama peradangan pada [[asma]] dan [[rhinitis]] alergik.<ins style="font-weight: bold; text-decoration: none;"><ref>David L. Nelson. [https://archive.org/details/lehningerprincip00lehn_1/page/359 Lehninger Principles of Biochemistry]. Macmillan. 2008. hlm. [https://archive.org/details/lehningerprincip00lehn_1/page/359 359]. ISBN 978-0-7167-7108-1.</ref> </ins>[[Antagonis leukotriena]] digunakan untuk mengobati gangguan ini dengan menghambat produksi atau aktivitas leukotriena.<ins style="font-weight: bold; text-decoration: none;"><ref>''Antileukotriene agents for the treatment of lung disease''. ''Am. J. Respir. Crit. Care Med''. September 2018. Vol. 188 (5). hlm. 538–544. doi:10.1164/rccm.201301-0023PP.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Referensi ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Referensi ==</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><references /></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Sumber dan atribusi ==</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Leukotriena&oldid=29568299 Wikipedia bahasa Indonesia], revisi 29568299 (2026-08-12T22:39:41Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Gambar pada artikel ini bersumber dari Wikimedia Commons dan mengikuti ketentuan lisensi masing-masing berkas. Mohon gunakan konten dan media secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== Sumber dan atribusi ==</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><!</ins>-- <ins style="font-weight: bold; text-decoration: none;">WIKI_UNISSULA_PRESENTATION_V4 </ins>--<ins style="font-weight: bold; text-decoration: none;">></ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Leukotriena&oldid=29568299 Wikipedia bahasa Indonesia], revisi 29568299 (2026</del>-<del style="font-weight: bold; text-decoration: none;">08</del>-<del style="font-weight: bold; text-decoration: none;">12T22:39:41Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi</del>-<del style="font-weight: bold; text-decoration: none;">BerbagiSerupa (CC BY</del>-<del style="font-weight: bold; text-decoration: none;">SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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Maintenance script: Impor teks terkontrol dari Wikipedia bahasa Indonesia; revisi 29568299; atribusi sumber disertakan.
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<p>Impor teks terkontrol dari Wikipedia bahasa Indonesia; revisi 29568299; atribusi sumber disertakan.</p>
<p><b>Halaman baru</b></p><div>'''Leukotriena''' adalah famili [[Radang|mediator inflamasi]] [[eikosanoid]] yang diproduksi dalam [[sel darah putih]] oleh [[Redoks|oksidasi]] [[asam arakidonat]] (AA) dan [[asam lemak esensial]] yaitu [[asam eikosapentanoat]] (EPA) oleh [[enzim]] [[5-lipokigenase arakidonat]].<br />
<br />
Leukotriena menggunakan [[persinyalan lipid]] untuk menyampaikan informasi baik ke sel yang memproduksinya ([[persinyalan autokrin]]) atau sel-sel tetangga ([[persinyalan parakrin]]) untuk mengatur respons imun. Produksi leukotriena biasanya disertai dengan produksi [[histamin]] dan [[prostaglandin]], yang juga bertindak sebagai mediator inflamasi.<br />
<br />
Salah satu peran mereka (khususnya, [[Leukotriena D4|leukotriena D<sub>4</sub>]]) adalah memicu kontraksi pada otot polos yang melapisi bronkiolus; produksi berlebih leukotriena merupakan penyebab utama peradangan pada [[asma]] dan [[rhinitis]] alergik. [[Antagonis leukotriena]] digunakan untuk mengobati gangguan ini dengan menghambat produksi atau aktivitas leukotriena.<br />
<br />
== Referensi ==<br />
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== Sumber dan atribusi ==<br />
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Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Leukotriena&oldid=29568299 Wikipedia bahasa Indonesia], revisi 29568299 (2026-08-12T22:39:41Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</div>
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