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Titrasi obat - Riwayat revisi
2026-09-15T19:33:32Z
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Maintenance script: Presentation V4: sitasi, referensi, Math, Wikimedia Commons, dan atribusi
2026-08-29T04:09:22Z
<p>Presentation V4: sitasi, referensi, Math, Wikimedia Commons, dan atribusi</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Revisi sebelumnya</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revisi per 29 Agustus 2026 04.09</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Baris 1:</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">'''Titrasi obat''' adalah proses penyesuaian </del>[[<del style="font-weight: bold; text-decoration: none;">dosis]] suatu [[medikasi</del>|<del style="font-weight: bold; text-decoration: none;">obat]] untuk mendapatkan manfaat maksimal tanpa [[efek samping</del>]]<del style="font-weight: bold; text-decoration: none;">.</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[<ins style="font-weight: bold; text-decoration: none;">File:Titrated_doses.svg|thumb|right|280px</ins>|<ins style="font-weight: bold; text-decoration: none;">Titrated doses</ins>]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Ketika suatu </del>obat <del style="font-weight: bold; text-decoration: none;">memiliki </del>[[<del style="font-weight: bold; text-decoration: none;">indeks terapeutik</del>]] <del style="font-weight: bold; text-decoration: none;">yang sempit, titrasi sangatlah penting, karena kisaran antara dosis efektif </del>suatu <del style="font-weight: bold; text-decoration: none;">obat dan dosis terjadinya efek samping kecil. Beberapa contoh jenis obat yang umumnya memerlukan titrasi antara lain </del>[[<del style="font-weight: bold; text-decoration: none;">insulin]], [[antikejang</del>|<del style="font-weight: bold; text-decoration: none;">antikonvulsan</del>]]<del style="font-weight: bold; text-decoration: none;">, </del>[[<del style="font-weight: bold; text-decoration: none;">antikoagulan|pengencer darah</del>]]<del style="font-weight: bold; text-decoration: none;">, </del>[<del style="font-weight: bold; text-decoration: none;">[antidepresan]], dan [[sedatif|obat penenang]</del>].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''Titrasi </ins>obat<ins style="font-weight: bold; text-decoration: none;">''' adalah proses penyesuaian </ins>[[<ins style="font-weight: bold; text-decoration: none;">dosis</ins>]] suatu [[<ins style="font-weight: bold; text-decoration: none;">medikasi</ins>|<ins style="font-weight: bold; text-decoration: none;">obat</ins>]] <ins style="font-weight: bold; text-decoration: none;">untuk mendapatkan manfaat maksimal tanpa </ins>[[<ins style="font-weight: bold; text-decoration: none;">efek samping</ins>]]<ins style="font-weight: bold; text-decoration: none;">.<ref></ins>[<ins style="font-weight: bold; text-decoration: none;">https://books.google.com/books?id=W-5kAgAAQBAJ&pg=PA34 Davidson's Principles and Practice of Medicine</ins>]. <ins style="font-weight: bold; text-decoration: none;">Elsevier Health Sciences. 2013. hlm. 34. ISBN 978-0-7020-5103-6.</ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Disarankan untuk melakukan </del>titrasi obat <del style="font-weight: bold; text-decoration: none;">dibandingkan menghentikannya secara tiba</del>-<del style="font-weight: bold; text-decoration: none;">tiba dalam beberapa situasi</del>. [[<del style="font-weight: bold; text-decoration: none;">Glukokortikoid</del>]] <del style="font-weight: bold; text-decoration: none;">harus dikurangi setelah penggunaan jangka panjang untuk menghindari insufisiensi adrenal</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Ketika suatu obat memiliki [[indeks terapeutik]] yang sempit, </ins>titrasi <ins style="font-weight: bold; text-decoration: none;">sangatlah penting, karena kisaran antara dosis efektif suatu </ins>obat <ins style="font-weight: bold; text-decoration: none;">dan dosis terjadinya efek samping kecil.<ref>[https://archive.org/details/clinicalpharmaco0000benn_v5q7 Clinical Pharmacology]. Elsevier. 2012. hlm. [https://archive.org/details/clinicalpharmaco0000benn_v5q7/page/74 74]–109. ISBN 978</ins>-<ins style="font-weight: bold; text-decoration: none;">0-7020-4084-9</ins>.<ins style="font-weight: bold; text-decoration: none;"></ref> Beberapa contoh jenis obat yang umumnya memerlukan titrasi antara lain [[insulin]], [[antikejang|antikonvulsan]], [[antikoagulan|pengencer darah]], </ins>[[<ins style="font-weight: bold; text-decoration: none;">antidepresan</ins>]]<ins style="font-weight: bold; text-decoration: none;">, dan [[sedatif|obat penenang]].<ref>''Principles of Clinical Pharmacology''. McGraw-Hill. 2014. ISBN 978-0-07-180215-4.</ref><ref>''Poisoning & Drug Overdose''. McGraw-Hill. 11 Desember 2017. ISBN 978-0-07-183979-2.</ref><ref>''Basic & Clinical Pharmacology''. McGraw-Hill. 30 November 2017. ISBN 978-1-259-64115-2</ins>.<ins style="font-weight: bold; text-decoration: none;"></ref></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Titrasi obat juga digunakan dalam [[uji klinis]] [[Tahap-tahap penelitian klinis#Tahap I|tahap I]]. [[Obat eksperimental]] diberikan dalam dosis yang meningkat hingga efek samping menjadi tidak dapat ditoleransi. Uji klinis yang menemukan dosis yang sesuai disebut [[studi rentang dosis]] (''dose-ranging study'').</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Disarankan untuk melakukan titrasi obat dibandingkan menghentikannya secara tiba-tiba dalam beberapa situasi. [[Glukokortikoid]] harus dikurangi setelah penggunaan jangka panjang untuk menghindari insufisiensi adrenal.<ref>[https://www.uptodate.com/contents/glucocorticoid-withdrawal Treatment Issues in Rheumatology]. ''UpToDate''.</ref></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Titrasi obat juga digunakan dalam [[uji klinis]] [[Tahap-tahap penelitian klinis#Tahap I|tahap I]]. [[Obat eksperimental]] diberikan dalam dosis yang meningkat hingga efek samping menjadi tidak dapat ditoleransi.<ins style="font-weight: bold; text-decoration: none;"><ref>[https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM073115.pdf Dose-Response Information to Support Drug Registration]. ''Guideline for Industry''. FDA. November 1994.</ref> </ins>Uji klinis yang menemukan dosis yang sesuai disebut [[studi rentang dosis]] (''dose-ranging study'').</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Lihat pula==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Lihat pula==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [[Pemantauan obat terapeutik]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [[Pemantauan obat terapeutik]]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">==Referensi==</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Referensi ==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><references /></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Sumber dan atribusi ==</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== <del style="font-weight: bold; text-decoration: none;">Sumber </del>dan <del style="font-weight: bold; text-decoration: none;">atribusi ==</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title</ins>=<ins style="font-weight: bold; text-decoration: none;">Titrasi+obat&oldid</ins>=<ins style="font-weight: bold; text-decoration: none;">25148417 Wikipedia bahasa Indonesia], revisi 25148417 (2024-01-09T23:52:06Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Gambar pada artikel ini bersumber dari Wikimedia Commons </ins>dan <ins style="font-weight: bold; text-decoration: none;">mengikuti ketentuan lisensi masing-masing berkas. Mohon gunakan konten dan media secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Titrasi+obat&oldid=25148417 Wikipedia bahasa Indonesia], revisi 25148417 (2024</del>-<del style="font-weight: bold; text-decoration: none;">01</del>-<del style="font-weight: bold; text-decoration: none;">09T23:52:06Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi</del>-<del style="font-weight: bold; text-decoration: none;">BerbagiSerupa (CC BY</del>-<del style="font-weight: bold; text-decoration: none;">SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><!</ins>-- <ins style="font-weight: bold; text-decoration: none;">WIKI_UNISSULA_PRESENTATION_V4 </ins>--<ins style="font-weight: bold; text-decoration: none;">></ins></div></td></tr>
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Maintenance script: Impor teks terkontrol dari Wikipedia bahasa Indonesia; revisi 25148417; atribusi sumber disertakan.
2026-08-29T03:34:58Z
<p>Impor teks terkontrol dari Wikipedia bahasa Indonesia; revisi 25148417; atribusi sumber disertakan.</p>
<p><b>Halaman baru</b></p><div>'''Titrasi obat''' adalah proses penyesuaian [[dosis]] suatu [[medikasi|obat]] untuk mendapatkan manfaat maksimal tanpa [[efek samping]].<br />
<br />
Ketika suatu obat memiliki [[indeks terapeutik]] yang sempit, titrasi sangatlah penting, karena kisaran antara dosis efektif suatu obat dan dosis terjadinya efek samping kecil. Beberapa contoh jenis obat yang umumnya memerlukan titrasi antara lain [[insulin]], [[antikejang|antikonvulsan]], [[antikoagulan|pengencer darah]], [[antidepresan]], dan [[sedatif|obat penenang]].<br />
<br />
Disarankan untuk melakukan titrasi obat dibandingkan menghentikannya secara tiba-tiba dalam beberapa situasi. [[Glukokortikoid]] harus dikurangi setelah penggunaan jangka panjang untuk menghindari insufisiensi adrenal.<br />
<br />
Titrasi obat juga digunakan dalam [[uji klinis]] [[Tahap-tahap penelitian klinis#Tahap I|tahap I]]. [[Obat eksperimental]] diberikan dalam dosis yang meningkat hingga efek samping menjadi tidak dapat ditoleransi. Uji klinis yang menemukan dosis yang sesuai disebut [[studi rentang dosis]] (''dose-ranging study'').<br />
==Lihat pula==<br />
* [[Pemantauan obat terapeutik]]<br />
==Referensi==<br />
<br />
<br />
<br />
== Sumber dan atribusi ==<br />
<br />
Konten artikel ini diadaptasi dari [https://id.wikipedia.org/w/index.php?title=Titrasi+obat&oldid=25148417 Wikipedia bahasa Indonesia], revisi 25148417 (2024-01-09T23:52:06Z), yang tersedia berdasarkan lisensi Creative Commons Atribusi-BerbagiSerupa (CC BY-SA). Mohon gunakan konten ini secara bijak serta sesuai dengan ketentuan lisensi yang berlaku.</div>
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