KCNJ12
Saluran kalium penyearah ke dalam yang peka terhadap ATP, saluran kalium 12 adalah saluran ion berpagar lipid yang pada manusia dikodekan oleh gen KCNJ12.[1][2][3][4][5]
Fungsi
Gen ini mengkode saluran K+ penyearah ke dalam yang dapat diblokir oleh kation divalen. Protein ini dianggap sebagai salah satu dari beberapa saluran penyearah ke dalam yang berkontribusi pada arus penyearah ke dalam jantung (IK1). Gen ini terletak di dalam wilayah sindrom Smith-Magenis pada kromosom 17.[6]
Interaksi
KCNJ12 telah terbukti berinteraksi dengan:
- APBA1,[7][8]
- CASK,[9][10]
- DLG1,[11][12][13]
- DLG2,[14]
- DLG3,[15]
- DLG4,[16][17]
- LIN7A[18][19]
- LIN7B,[20][21] and
- LIN7C.[22][23]
Pranala luar
- Saluran Kir2.2+ di Perpustakaan Nasional AS untuk Medical Subject Headings (MeSH/Judul Subjek Medis)
Referensi
- ↑ SB Hansen. Lipid agonism: The PIP2 paradigm of ligand-gated ion channels. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. May 2015. Vol. 1851 (5). hlm. 620–8. doi:10.1016/j.bbalip.2015.01.011.
- ↑ Cloning and functional expression of an inwardly rectifying K+ channel from human atrium. Circulation Research. Mar 1995. Vol. 76 (3). hlm. 343–50. doi:10.1161/01.res.76.3.343.
- ↑ Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes. FEBS Letters. Nov 2002. Vol. 531 (2). hlm. 250–4. doi:10.1016/S0014-5793(02)03512-3.
- ↑ International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacological Reviews. Dec 2005. Vol. 57 (4). hlm. 509–26. doi:10.1124/pr.57.4.11.
- ↑ Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12.
- ↑ Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12.
- ↑ Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemistry. May 2004. Vol. 279 (21). hlm. 22331–46. doi:10.1074/jbc.M400285200.
- ↑ A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. The Journal of Biological Chemistry. Apr 2004. Vol. 279 (18). hlm. 19051–63. doi:10.1074/jbc.M400284200.
- ↑ Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemistry. May 2004. Vol. 279 (21). hlm. 22331–46. doi:10.1074/jbc.M400285200.
- ↑ A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. The Journal of Biological Chemistry. Apr 2004. Vol. 279 (18). hlm. 19051–63. doi:10.1074/jbc.M400284200.
- ↑ Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemistry. May 2004. Vol. 279 (21). hlm. 22331–46. doi:10.1074/jbc.M400285200.
- ↑ A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. The Journal of Biological Chemistry. Apr 2004. Vol. 279 (18). hlm. 19051–63. doi:10.1074/jbc.M400284200.
- ↑ Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. Journal of Cell Science. Mar 2001. Vol. 114 (Pt 5). hlm. 987–98. doi:10.1242/jcs.114.5.987.
- ↑ Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemistry. May 2004. Vol. 279 (21). hlm. 22331–46. doi:10.1074/jbc.M400285200.
- ↑ Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemistry. May 2004. Vol. 279 (21). hlm. 22331–46. doi:10.1074/jbc.M400285200.
- ↑ Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemistry. May 2004. Vol. 279 (21). hlm. 22331–46. doi:10.1074/jbc.M400285200.
- ↑ A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. The Journal of Biological Chemistry. Apr 2004. Vol. 279 (18). hlm. 19051–63. doi:10.1074/jbc.M400284200.
- ↑ Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemistry. May 2004. Vol. 279 (21). hlm. 22331–46. doi:10.1074/jbc.M400285200.
- ↑ A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. The Journal of Biological Chemistry. Apr 2004. Vol. 279 (18). hlm. 19051–63. doi:10.1074/jbc.M400284200.
- ↑ Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemistry. May 2004. Vol. 279 (21). hlm. 22331–46. doi:10.1074/jbc.M400285200.
- ↑ A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. The Journal of Biological Chemistry. Apr 2004. Vol. 279 (18). hlm. 19051–63. doi:10.1074/jbc.M400284200.
- ↑ Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemistry. May 2004. Vol. 279 (21). hlm. 22331–46. doi:10.1074/jbc.M400285200.
- ↑ A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. The Journal of Biological Chemistry. Apr 2004. Vol. 279 (18). hlm. 19051–63. doi:10.1074/jbc.M400284200.
Sumber dan atribusi
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