Faktor PTA

Faktor PTA atau faktor XI () adalah zimogen dari jenis serina protease yang merupakan prekursor dari faktor XIa, yang disekresi ke dalam sirkulasi darah untuk mengaktivasi plasma tromboplastin intrinsik^[1] saat darah terpapar oleh permukaan asing.^[2] Pada manusia, FXI terkodikasi dalam gen F11.^[3]^[4]^[5]^[6]

FXI disintesis oleh hati dan disekresi dalam bentuk homo-dimer yang tidak aktif^[7] dengan waktu paruh sekitar 52 jam dan rasio plasma sekitar 5 mcg/mL.^[8]

Pranala luar

UAB Coagulation Service . Department of Pathology, UAB Hospital.

Bacaan lanjut

High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis . New England Journal of Medicine; Joost C.M. Meijers, Winnie L.H. Tekelenburg, et al.

Referensi

↑ Factors. Farlex free dictionary.
↑ Factor XI. Answer.com.
↑ Fujikawa K, Chung DW, Hendrickson LE, Davie EW. Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein. Biochemistry. 1986. Vol. 25 (9). hlm. 2417–24. doi:10.1021/bi00357a018.
↑ Asakai R, Davie EW, Chung DW. Organization of the gene for human factor XI. Biochemistry. 1987. Vol. 26 (23). hlm. 7221–8. doi:10.1021/bi00397a004.
↑ Kato A, Asakai R, Davie EW, Aoki N. Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4. Cytogenet. Cell Genet. 1989. Vol. 52 (1-2). hlm. 77–8. doi:10.1159/000132844.
↑ Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, Wasmuth JJ, Wood S, Berdahl LD, Leysens NJ. A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates. Am. J. Hum. Genet. 1991. Vol. 48 (5). hlm. 911–25.
↑ Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN. Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa. J. Biol. Chem. 2008. Vol. 283 (27). hlm. 18655–64. doi:10.1074/jbc.M802275200.
↑ Factor XI Deficiency. Cardeza Foundation Hemophilia Treatment Center, Thomas Jefferson University; Jamie E Siegel.

Sumber dan atribusi

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[1] Factors. Farlex free dictionary.

[2] Factor XI. Answer.com.

[3] Fujikawa K, Chung DW, Hendrickson LE, Davie EW. Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein. Biochemistry. 1986. Vol. 25 (9). hlm. 2417–24. doi:10.1021/bi00357a018.

[4] Asakai R, Davie EW, Chung DW. Organization of the gene for human factor XI. Biochemistry. 1987. Vol. 26 (23). hlm. 7221–8. doi:10.1021/bi00397a004.

[5] Kato A, Asakai R, Davie EW, Aoki N. Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4. Cytogenet. Cell Genet. 1989. Vol. 52 (1-2). hlm. 77–8. doi:10.1159/000132844.

[6] Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, Wasmuth JJ, Wood S, Berdahl LD, Leysens NJ. A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates. Am. J. Hum. Genet. 1991. Vol. 48 (5). hlm. 911–25.

[7] Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN. Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa. J. Biol. Chem. 2008. Vol. 283 (27). hlm. 18655–64. doi:10.1074/jbc.M802275200.

[8] Factor XI Deficiency. Cardeza Foundation Hemophilia Treatment Center, Thomas Jefferson University; Jamie E Siegel.

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