Affinisina

Affinisine adalah alkaloid indol monoterpena yang dapat diisolasi dari tanaman genus Tabernaemontana.^[1]^[2] Secara struktural, Affinisine dapat dianggap sebagai anggota keluarga alkaloid sarpagine dan dapat disintesis dari triptofan melalui reaksi Pictet-Spengler.^[3]^[4]

Farmakologi

Pengujian farmakologis terbatas telah menunjukkan bahwa affinisine dapat secara efektif menghambat asetilkolinesterase dan butirilkolinesterase.^[5]^[6]

Referensi

↑ Marcelo T. Andrade. Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme. Bioorganic & Medicinal Chemistry. Juni 2005. Vol. 13 (12). hlm. 4092–4095. doi:10.1016/j.bmc.2005.03.045.
↑ Pascale Clivio. Alkaloids from leaves and root bark ofErvatamia hirta. Phytochemistry. Januari 1991. Vol. 30 (11). hlm. 3785–3792. doi:10.1016/0031-9422(91)80111-D.
↑ Xiaoxiang Liu. Enantiospecific total synthesis of the enantiomer of the indole alkaloid affinisine. Tetrahedron Letters. Agustus 2000. Vol. 41 (33). hlm. 6299–6303. doi:10.1016/S0040-4039(00)01061-3.
↑ Xuebin Liao. An Improved Total Synthesis of (+)-Macroline and Alstonerine as Well as the Formal Total Synthesis of (−)-Talcarpine and (−)-Anhydromacrosalhine−methine. The Journal of Organic Chemistry. November 2006. Vol. 71 (23). hlm. 8884–8890. doi:10.1021/jo061652u.
↑ Marcelo T. Andrade. Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme. Bioorganic & Medicinal Chemistry. Juni 2005. Vol. 13 (12). hlm. 4092–4095. doi:10.1016/j.bmc.2005.03.045.
↑ Ivo J.C. Vieira. Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures. Anais da Academia Brasileira de Ciências. September 2008. Vol. 80 (3). hlm. 419–426. doi:10.1590/S0001-37652008000300003.

Sumber dan atribusi

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[1] Marcelo T. Andrade. Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme. Bioorganic & Medicinal Chemistry. Juni 2005. Vol. 13 (12). hlm. 4092–4095. doi:10.1016/j.bmc.2005.03.045.

[2] Pascale Clivio. Alkaloids from leaves and root bark ofErvatamia hirta. Phytochemistry. Januari 1991. Vol. 30 (11). hlm. 3785–3792. doi:10.1016/0031-9422(91)80111-D.

[3] Xiaoxiang Liu. Enantiospecific total synthesis of the enantiomer of the indole alkaloid affinisine. Tetrahedron Letters. Agustus 2000. Vol. 41 (33). hlm. 6299–6303. doi:10.1016/S0040-4039(00)01061-3.

[4] Xuebin Liao. An Improved Total Synthesis of (+)-Macroline and Alstonerine as Well as the Formal Total Synthesis of (−)-Talcarpine and (−)-Anhydromacrosalhine−methine. The Journal of Organic Chemistry. November 2006. Vol. 71 (23). hlm. 8884–8890. doi:10.1021/jo061652u.

[5] Marcelo T. Andrade. Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme. Bioorganic & Medicinal Chemistry. Juni 2005. Vol. 13 (12). hlm. 4092–4095. doi:10.1016/j.bmc.2005.03.045.

[6] Ivo J.C. Vieira. Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures. Anais da Academia Brasileira de Ciências. September 2008. Vol. 80 (3). hlm. 419–426. doi:10.1590/S0001-37652008000300003.

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